Engraftment and Host-Specific Differentiation in the Heart After Ischemic Myocardial Stimulation of Paracrine Pathways With Growth Factors Enhances Embryonic Stem Cell
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چکیده
Theo Kofidis, Jorg L. de Bruin, Toshiyuki Yamane, Masashi Tanaka, Darren R. Lebl, Injury Engraftment and Host-Specific Differentiation in the Heart After Ischemic Myocardial Stimulation of Paracrine Pathways With Growth Factors Enhances Embryonic Stem Cell Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000165063.09283.A8 2005;111:2486-2493; originally published online May 9, 2005; Circulation. http://circ.ahajournals.org/content/111/19/2486 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://circ.ahajournals.org/content/suppl/2005/04/16/01.CIR.0000165063.09283.A8.DC1.html Data Supplement (unedited) at:
منابع مشابه
Stimulation of paracrine pathways with growth factors enhances embryonic stem cell engraftment and host-specific differentiation in the heart after ischemic myocardial injury.
BACKGROUND Growth factors play an essential role in organogenesis. We examine the potential of growth factors to enhance cell engraftment and differentiation and to promote functional improvement after transfer of undifferentiated embryonic stem cells into the injured heart. METHODS AND RESULTS Green fluorescent protein (GFP)-positive embryonic stem cells derived from 129sv mice were injected...
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It was assumed that the loss of cardiomyocytes is irreversible. The main goal is to develop widely available and clinically applicable treatments for heart diseases. The several studies have showed that the use of stem cells can improve complicacies such as cardiovascular diseases. Stem cells have a potential benefit of the self-renewal and cell differentiation into the cell types that can play...
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Cardiovascular disease remains the leading cause of morbidity and mortality in the United States and Europe. In recent years, the understanding that regenerative processes exist at the level of the myocardium, has placed stem cell research at center stage in cardiology. A stem cell is a cell that has the ability to divide (self replicate) for indefinite periods often throughout the life of the ...
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Background: Human embryonic stem cells (hESC), which are derived from the inner cell mass of the blastocysts, have been considered to be pluripotent cells. In this study we examine the differentiating potential of hESC into hepatocytes by characterization of the expression of endoderm and liver-specific genes. Methods: hESC were cultivated in suspension to form aggregates, the embryoid bodies. ...
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Because the fundamental defect in both acute myocardial infarction (MI) and ischemic cardiomyopathy is myocyte loss, stem cell therapy to regenerate lost myocardium is conceptually appealing. Multiple clinical trials have been performed in patients with acute MI and chronic ischemic heart failure using a variety of cell types, including bone marrow stem cells, mesenchymal stem cells (MSCs), and...
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تاریخ انتشار 2005